癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-CLPTM1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O96005 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 3090 |
| Calculated MW | 76097 Da |
| Gene Name | CLPTM1 |
| Aliases | CLPTM1; CLPTM1 Regulator Of GABA Type A Receptor Forward Trafficking; Cleft Lip And Palate Associated Transmembrane Protein 1; Cleft Lip And Palate Transmembrane Protein 1; Putative Lipid Scramblase CLPTM1; CLPTM1, Transmembrane Protein |
| Immunogen | A synthesized peptide derived from CLPTM1 |
| Gene ID | 1209 |
|---|---|
| Other Names | Putative lipid scramblase CLPTM1, Cleft lip and palate transmembrane protein 1, CLPTM1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CLPTM1 |
|---|---|
| Function | Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate (By similarity). Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one (By similarity). Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI- anchored proteins (GPI-APs) from protein folding to transport states (PubMed:29255114). May play a role in T-cell development (By similarity). |
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed.. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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