癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-CDC23 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q9UJX2 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB3420 |
| Calculated MW | 68834 Da |
| Gene Name | CDC23 |
| Aliases | CDC23; Cell Division Cycle 23; ANAPC8; APC8; CUT23; Cell Division Cycle Protein 23 Homolog; Anaphase-Promoting Complex Subunit 8; Cyclosome Subunit 8; CDC23 (Cell Division Cycle 23, Yeast, Homolog); Cell Division Cycle 23 Homolog (S. Cerevisiae); Anaphase Promoting Complex Subunit 8; Cell Division Cycle 23 Homolog |
| Immunogen | A synthesized peptide derived from human Cdc23/APC8 |
| Gene ID | 8697 |
|---|---|
| Other Names | Cell division cycle protein 23 homolog, Anaphase-promoting complex subunit 8, APC8, Cyclosome subunit 8, CDC23, ANAPC8 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CDC23 |
|---|---|
| Synonyms | ANAPC8 |
| Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:18485873, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys- 48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861). |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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