癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Calpain 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P07384 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 3290 |
| Calculated MW | 81890 Da |
| Gene Name | CAPN1 |
| Aliases | CAPN1; Calpain 1; CANPL1; MuCANP; CANP; Cell Proliferation-Inducing Gene 30 Protein; Calcium-Activated Neutral Proteinase 1; Calpain 1, (Mu/I) Large Subunit; Calpain-1 Catalytic Subunit; Calpain-1 Large Subunit; Micromolar-Calpain; Calpain Mu-Type; EC 3.4.22.52; CANP; MuCL; Cell Proliferation-Inducing Protein 30; Calpain, Large Polypeptide L1; EC 3.4.22; MUCANP; CANP1; SPG76; MUCL |
| Immunogen | A synthesized peptide derived from human Calpain 1 catalytic subunit |
| Gene ID | 823 |
|---|---|
| Other Names | Calpain-1 catalytic subunit, 3.4.22.52, Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Cell proliferation-inducing gene 30 protein {ECO:0000303|Ref.3}, Micromolar-calpain, muCANP, CAPN1 (HGNC:1476), CANPL1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CAPN1 (HGNC:1476) |
|---|---|
| Synonyms | CANPL1 |
| Function | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). Cleaves and activates caspase-7 (CASP7) (PubMed:19617626). |
| Cellular Location | Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719) |
| Tissue Location | Ubiquitous. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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