癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-CBX2 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q14781 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 3345 |
| Calculated MW | 56081 Da |
| Gene Name | CBX2 |
| Aliases | CBX2; Chromobox 2; M33; Cell Division Cycle Associated 6; Chromobox Protein Homolog 2; MGC10561; CDCA6; Chromobox Homolog 2 (Pc Class Homolog, Drosophila); Chromobox Homolog 2 (Drosophila Pc Class); Pc Class Homolog (Drosophila); Chromobox Homolog 2; Pc Class Homolog; Modifier 3; SRXY5 |
| Immunogen | A synthesized peptide derived from human CBX2 |
| Gene ID | 84733 |
|---|---|
| Other Names | Chromobox protein homolog 2, CBX2 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CBX2 |
|---|---|
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780). |
| Cellular Location | Nucleus. Chromosome Note=Localized in distinct foci on chromatin and in chromocenters Localizes to the inactive X chromosome. Seems to be recruited to H3K27me3, H3K9ac and H3K3me2 sites on chromatin |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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