癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Histone deacetylase 8 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9BY41 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB2495 |
| Calculated MW | 41758 Da |
| Gene Name | HDAC8 |
| Aliases | HDAC8; Histone Deacetylase 8; HDACL1; KDAC8; RPD3; Protein Decrotonylase HDAC8; Histone Deacetylase-Like 1; Protein Deacetylase HDAC8; MRXS6; HD8; WTS; Wilson-Turner X-Linked Mental Retardation Syndrome; EC 3.5.1.98; EC 3.5.1.-; CDA07; CDLS5 |
| Immunogen | A synthesized peptide derived from human PKM2 |
| Gene ID | 55869 |
|---|---|
| Other Names | Histone deacetylase 8, HD8, 3.5.1.98, Protein deacetylase HDAC8, 3.5.1.-, Protein decrotonylase HDAC8, 3.5.1.-, HDAC8 {ECO:0000303|PubMed:10926844, ECO:0000312|HGNC:HGNC:13315} |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HDAC8 {ECO:0000303|PubMed:10926844, ECO:0000312|HGNC:HGNC:13315} |
|---|---|
| Function | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748). Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin (PubMed:22885700). May play a role in smooth muscle cell contractility (PubMed:15772115). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (PubMed:28497810). |
| Cellular Location | Nucleus. Chromosome Cytoplasm Note=Excluded from the nucleoli (PubMed:10748112). Found in the cytoplasm of cells showing smooth muscle differentiation (PubMed:15772115, PubMed:16538051). |
| Tissue Location | Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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