癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Phospholipase A2 activating protein Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9Y263 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2560 |
| Calculated MW | 87157 Da |
| Gene Name | PLAA |
| Aliases | PLAA; Phospholipase A2 Activating Protein; PLA2P; PLAP; DOA1; Phospholipase A-2-Activating Protein; FLJ11281; FLJ12699; DOA1 Homolog (S. Cerevisiae); DOA1 Homolog; NDMSBA |
| Immunogen | A synthesized peptide derived from human PLAP |
| Gene ID | 9373 |
|---|---|
| Other Names | Phospholipase A-2-activating protein, PLA2P, PLAP, PLAA, PLAP |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PLAA |
|---|---|
| Synonyms | PLAP |
| Function | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). |
| Cellular Location | Nucleus. Cytoplasm. Synapse {ECO:0000250|UniProtKB:P27612}. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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