癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-BAZ1B Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9UIG0 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB3685 |
| Calculated MW | 170903 Da |
| Gene Name | BAZ1B |
| Aliases | BAZ1B; Bromodomain Adjacent To Zinc Finger Domain 1B; WSTF; WBSCR10; WBSCR9; Williams-Beuren Syndrome Chromosomal Region 10 Protein; Williams-Beuren Syndrome Chromosomal Region 9 Protein; Williams Syndrome; Transcription Factor; Tyrosine-Protein Kinase BAZ1B; Transcription Factor; WSTF; EC 2.7.10.2; HWALp2; Bromodomain Adjacent To Zinc Finger Domain Protein 1B; Williams-Beuren Syndrome Chromosome Region 10; Williams-Beuren Syndrome Chromosome Region 9; WBSC10 |
| Immunogen | A synthesized peptide derived from human WSTF |
| Gene ID | 9031 |
|---|---|
| Other Names | Tyrosine-protein kinase BAZ1B, 2.7.10.2, Bromodomain adjacent to zinc finger domain protein 1B, Williams syndrome transcription factor, Williams-Beuren syndrome chromosomal region 10 protein, Williams-Beuren syndrome chromosomal region 9 protein, hWALp2, BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | BAZ1B |
|---|---|
| Synonyms | WBSC10, WBSCR10, WBSCR9, WSTF |
| Function | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (PubMed:19092802). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802, PubMed:19234442). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802, PubMed:19234442). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (PubMed:28801535). The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (By similarity). Within the B-WICH complex has a role in RNA polymerase III transcription (PubMed:16603771). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (PubMed:15543136). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063, ECO:0000255|PROSITE-ProRule:PRU00475, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMed:16603771, ECO:0000269|PubMed:25593309}. Note=Accumulates in pericentromeric heterochromatin during replication (PubMed:15543136). Co-localizes with PCNA at replication foci during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H at replication foci during late-S phase (PubMed:15543136). Also localizes to replication foci independently of SMARCA5/SNF2H and PCNA (PubMed:15543136). Localizes to sites of DNA damage (PubMed:25593309). |
| Tissue Location | Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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