癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Mitotic Arrest Deficient 1 Like 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9Y6D9 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3060 |
| Calculated MW | 83067 Da |
| Gene Name | MAD1L1 |
| Aliases | MAD1L1; Mitotic Arrest Deficient 1 Like 1; TXBP181; MAD1; HsMAD1; TP53I9; PIG9; Mitotic Spindle Assembly Checkpoint Protein MAD1; Mitotic Arrest Deficient 1-Like Protein 1; Mitotic Checkpoint MAD1 Protein Homolog; MAD1 Mitotic Arrest Deficient Like 1; Tax-Binding Protein 181; MAD1-Like Protein 1; MAD1 (Mitotic Arrest Deficient, Yeast, Homolog)-Like 1; Mitotic-Arrest Deficient 1, Yeast, Homolog-Like 1; MAD1 Mitotic Arrest Deficient-Like 1 (Yeast); Tumor Protein P53 Inducible Protein 9; HMAD1; MVA7 |
| Immunogen | A synthesized peptide derived from human MAD1 |
| Gene ID | 8379 |
|---|---|
| Other Names | Mitotic spindle assembly checkpoint protein MAD1, Mitotic arrest deficient 1-like protein 1, MAD1-like protein 1, Mitotic checkpoint MAD1 protein homolog, HsMAD1, hMAD1, Tax-binding protein 181, MAD1L1, MAD1, TXBP181 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MAD1L1 |
|---|---|
| Synonyms | MAD1, TXBP181 |
| Function | Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). |
| Cellular Location | Nucleus. Chromosome, centromere, kinetochore. Nucleus envelope Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Co- localizes with TPR at the nucleus envelope during interphase and throughout the cell cycle (PubMed:18981471, PubMed:22351768). From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody (PubMed:9546394). Localizes to kinetochores during prometaphase (PubMed:22351768, PubMed:29162720). Does not localize to kinetochores during metaphase (PubMed:29162720) Colocalizes with NEK2 at the kinetochore (PubMed:14978040). Colocalizes with IK at spindle poles during metaphase and anaphase (PubMed:22351768). |
| Tissue Location | [Isoform 1]: Expressed in hepatocellular carcinomas and hepatoma cell lines (at protein level) |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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