癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-BUB3 Mitotic Checkpoint Protein Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O43684 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3085 |
| Calculated MW | 37155 Da |
| Gene Name | BUB3 |
| Aliases | BUB3; BUB3 Mitotic Checkpoint Protein; BUB3L; Mitotic Checkpoint Protein BUB3; BUB3 (Budding Uninhibited By Benzimidazoles 3, Yeast) Homolog; Budding Uninhibited By Benzimidazoles 3 Homolog (Yeast); BUB3 Budding Uninhibited By Benzimidazoles 3 Homolog; Budding Uninhibited By Benzimidazoles 3 Homolog; Testicular Tissue Protein Li 27; Budding Uninhibited By Benomyl; Mitotic Checkpoint Component; HBUB3 |
| Immunogen | A synthesized peptide derived from human Bub3 |
| Gene ID | 9184 |
|---|---|
| Other Names | Mitotic checkpoint protein BUB3, BUB3 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | BUB3 |
|---|---|
| Function | Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. |
| Cellular Location | Nucleus. Chromosome, centromere, kinetochore. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I- anaphase I (MI-AI) transition. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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