癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-SBDS Ribosome MatuRation Factor Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9Y3A5 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3180 |
| Calculated MW | 28764 Da |
| Gene Name | SBDS |
| Aliases | SBDS; SBDS Ribosome Maturation Factor; CGI-97; SWDS; SDO1; SDS; SBDS, Ribosome Assembly Guanine Nucleotide Exchange Factor; Ribosome Maturation Protein SBDS; FLJ10917; Shwachman-Bodian-Diamond Syndrome Protein; Shwachman-Bodian-Diamond Syndrome |
| Immunogen | A synthesized peptide derived from human SBDS |
| Gene ID | 51119 |
|---|---|
| Other Names | Ribosome maturation protein SBDS, Shwachman-Bodian-Diamond syndrome protein, SBDS |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SBDS |
|---|---|
| Function | Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. |
| Cellular Location | Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:17475909, PubMed:19602484). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903). |
| Tissue Location | Widely expressed. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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