癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Intraflagellar transport 88 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q13099 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB4015 |
| Calculated MW | 93192 Da |
| Gene Name | IFT88 |
| Aliases | IFT88; Intraflagellar Transport 88; D13S1056E; TG737; TTC10; Recessive Polycystic Kidney Disease Protein Tg737 Homolog; Intraflagellar Transport Protein 88 Homolog; Tetratricopeptide Repeat Protein 10; Tetratricopeptide Repeat Domain 10; TPR Repeat Protein 10; Polaris Homolog; MGC26259; HTg737; Probe HTg737 (Polycystic Kidney Disease, Autosomal Recessive); Intraflagellar Transport 88 Homolog (Chlamydomonas); Intraflagellar Transport 88 Homolog; Testicular Tissue Protein Li 93; HTG737; Tg737; DAF19 |
| Immunogen | A synthesized peptide derived from human IFT88 |
| Gene ID | 8100 |
|---|---|
| Other Names | Intraflagellar transport protein 88 homolog, Recessive polycystic kidney disease protein Tg737 homolog, Tetratricopeptide repeat protein 10, TPR repeat protein 10, IFT88, TG737, TTC10 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | IFT88 |
|---|---|
| Synonyms | TG737, TTC10 |
| Function | Positively regulates primary cilium biogenesis (PubMed:17604723). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q61371}. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm {ECO:0000250|UniProtKB:Q61371}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q61371}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q61371}. Note=Colocalizes with ENTR1 and gamma- tubulin at the basal body of primary cilia (PubMed:27767179) Colocalizes with ENTR1 and pericentrin at the centrosome (PubMed:27767179). In sperm cells, localizes to the manchette, head- tail coupling apparatus and flagellum. Localizes to the manchette in elongating spermatids in a CFAP70-dependent manner (By similarity) {ECO:0000250|UniProtKB:Q61371, ECO:0000269|PubMed:27767179} |
| Tissue Location | Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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