癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-CRADD Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | P78560 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3380 |
| Calculated MW | 22745 Da |
| Gene Name | CRADD |
| Aliases | CRADD; CASP2 And RIPK1 Domain Containing Adaptor With Death Domain; RAIDD; RIP-Associated ICH1/CED3-Homologous Protein With Death Domain; Death Domain-Containing Protein CRADD; RIP-Associated Protein With A Death Domain; Caspase And RIP Adaptor With Death Domain; Caspase And RIP Adapter With Death Domain; Death Domain Containing Protein CRADD; Death Adaptor Molecule RAIDD; CRADD/LYZ Fusion; MRT34 |
| Immunogen | A synthesized peptide derived from human RAIDD |
| Gene ID | 8738 |
|---|---|
| Other Names | Death domain-containing protein CRADD, Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD, RAIDD |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CRADD |
|---|---|
| Synonyms | RAIDD |
| Function | Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572, PubMed:9044836). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:O88843}. Nucleus {ECO:0000250|UniProtKB:O88843} |
| Tissue Location | Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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