癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-RCHY1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | Q96PM5 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 25GB3545 |
| Calculated MW | 30110 Da |
| Gene Name | RCHY1 |
| Aliases | RCHY1; Ring Finger And CHY Zinc Finger Domain Containing 1; RNF199; ZNF363; CHIMP; ARNIP; PIRH2; PRO1996; ZCHY; RING Finger And CHY Zinc Finger Domain-Containing Protein 1; Androgen-Receptor N-Terminal-Interacting Protein; P53-Induced Protein With A RING-H2 Domain; RING-Type E3 Ubiquitin Transferase RCHY1; E3 Ubiquitin-Protein Ligase Pirh2; RING Finger Protein 199; Zinc Finger Protein 363; Zinc Finger, CHY-Type; DKFZp586C1620; Ring Finger And CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase; Androgen Receptor N-Terminal-Interacting Protein; CH-Rich Interacting Match With PLAG1; CH-Rich-Interacting Match With PLAG1; P53-Induced RING-H2 Protein; EC 2.3.2.27; HPirh2 |
| Immunogen | A synthesized peptide derived from human RCHY1 |
| Gene ID | 25898 |
|---|---|
| Other Names | RING finger and CHY zinc finger domain-containing protein 1, 2.3.2.27, Androgen receptor N-terminal-interacting protein, CH-rich-interacting match with PLAG1, E3 ubiquitin-protein ligase Pirh2, RING finger protein 199, RING-type E3 ubiquitin transferase RCHY1, Zinc finger protein 363, p53-induced RING-H2 protein, hPirh2, RCHY1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RCHY1 |
|---|---|
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:19043414, PubMed:19483087, PubMed:21994467). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (PubMed:19043414, PubMed:19483087). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:21791603). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (PubMed:33909987). |
| Cellular Location | Nucleus. Nucleus speckle. Cytoplasm |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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