癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-WD repeat domain 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O75083 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB4720 |
| Calculated MW | 66194 Da |
| Gene Name | WDR1 |
| Aliases | WDR1; WD Repeat Domain 1; AIP1; Actin-Interacting Protein 1; WD Repeat-Containing Protein 1; NORI-1; Epididymis Secretory Protein Li 52; HEL-S-52; PFITS |
| Immunogen | A synthesized peptide derived from human WDR1 |
| Gene ID | 9948 |
|---|---|
| Other Names | WD repeat-containing protein 1, Actin-interacting protein 1, AIP1, NORI-1, WDR1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | WDR1 |
|---|---|
| Function | Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5RKI0}. Cell projection, podosome. Cell junction |
| Tissue Location | Expressed in peripheral blood mononuclear cells (at protein level). |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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