癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-CCDC98 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | Q6UWZ7 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB4760 |
| Calculated MW | 46663 Da |
| Gene Name | ABRAXAS1 |
| Aliases | ABRAXAS1; Antibodyraxas 1, BRCA1 A Complex Subunit 2; ABRA1; FAM175A; CCDC98; Family With Sequence Similarity 175 Member A; BRCA1-A Complex Subunit Antibodyraxas 1; Coiled-Coil Domain Containing 98; Antibodyraxas Protein; FLJ13614; ABRAXAS; Family With Sequence Similarity 175, Member A; Coiled-Coil Domain-Containing Protein 98; Protein FAM175A |
| Immunogen | A synthesized peptide derived from human CCDC98 |
| Gene ID | 84142 |
|---|---|
| Other Names | BRCA1-A complex subunit Abraxas 1 {ECO:0000312|HGNC:HGNC:25829}, Coiled-coil domain-containing protein 98, Protein FAM175A, ABRAXAS1 (HGNC:25829) |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ABRAXAS1 (HGNC:25829) |
|---|---|
| Function | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
| Cellular Location | Nucleus Note=Localizes at sites of DNA damage at double-strand breaks (DSBs) |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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