癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Ephrin A1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P20827 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB5265 |
| Calculated MW | 23787 Da |
| Gene Name | EFNA1 |
| Aliases | EFNA1; Ephrin A1; LERK1; Ephrin-A1; TNFAIP4; ECKLG; EPLG1; GMAN ; Gastric Cancer Metastasis Associated Long Noncoding RNA; EPH-Related Receptor Tyrosine Kinase Ligand 1; Tumor Necrosis Factor Alpha-Induced Protein 4; Immediate Early Response Protein B61; TNF Alpha-Induced Protein 4; LERK-1; Tumor Necrosis Factor, Alpha-Induced Protein 4; Eph-Related Receptor Tyrosine Kinase Ligand 1; Epididymis Secretory Sperm Binding Protein; Ligand Of Eph-Related Kinase 1; EFL1; B61 |
| Immunogen | A synthesized peptide derived from human Ephrin A1 |
| Gene ID | 1942 |
|---|---|
| Other Names | Ephrin-A1, EPH-related receptor tyrosine kinase ligand 1, LERK-1, Immediate early response protein B61, Tumor necrosis factor alpha-induced protein 4, TNF alpha-induced protein 4, Ephrin-A1, secreted form, EFNA1, EPLG1, LERK1, TNFAIP4 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | EFNA1 |
|---|---|
| Synonyms | EPLG1, LERK1, TNFAIP4 |
| Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells (PubMed:17332925, PubMed:18794797). Involved in angiogenesis, regulating vascular endothelial cell differentiation and migration through activation of EPHA2. Acts as a ligand for EPHA3, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development (PubMed:12794130). May also contribute to dendritic spine morphogenesis (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor |
| Tissue Location | Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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