癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-GOPC Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9HD26 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB5870 |
| Calculated MW | 50520 Da |
| Gene Name | GOPC |
| Aliases | GOPC; Golgi Associated PDZ And Coiled-Coil Motif Containing; PIST; FIG; CAL; DJ94G16.2; GOPC1; Golgi-Associated PDZ And Coiled-Coil Motif-Containing Protein; PDZ Protein Interacting Specifically With TC10; CFTR-Associated Ligand; Fused In Glioblastoma; PDZ/Coiled-Coil Domain Binding Partner For The Rho-Family GTPase TC10; Golgi-Associated PDZ And Coiled-Coil Motif Containing Protein; DJ94G16.2 PIST |
| Immunogen | A synthesized peptide derived from human PIST |
| Gene ID | 57120 |
|---|---|
| Other Names | Golgi-associated PDZ and coiled-coil motif-containing protein {ECO:0000312|HGNC:HGNC:17643}, CFTR-associated ligand, Fused in glioblastoma, PDZ protein interacting specifically with TC10, PIST, GOPC (HGNC:17643) |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GOPC (HGNC:17643) |
|---|---|
| Function | Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). |
| Cellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein Synapse. Postsynaptic density. Cell projection, dendrite. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides. |
| Tissue Location | Ubiquitously expressed. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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