癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-GTF2I Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P78347 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB5950 |
| Calculated MW | 112416 Da |
| Gene Name | GTF2I |
| Aliases | GTF2I; General Transcription Factor IIi; TFII-I; SPIN; BAP-135; BTKAP1; WBSCR6; IB291; DIWS; Bruton Tyrosine Kinase-Associated Protein 135; General Transcription Factor II-I; SRF-Phox1-Interacting Protein; GTFII-I; BAP135; Williams-Beuren Syndrome Chromosomal Region 6 Protein; Williams-Beuren Syndrome Chromosome Region 6; General Transcription Factor II, I; BTK-Associated Protein, 135kD; BTK-Associated Protein 135; WBS |
| Immunogen | A synthesized peptide derived from human GTF2I |
| Gene ID | 2969 |
|---|---|
| Other Names | General transcription factor II-I, GTFII-I, TFII-I, Bruton tyrosine kinase-associated protein 135, BAP-135, BTK-associated protein 135, SRF-Phox1-interacting protein, SPIN, Williams-Beuren syndrome chromosomal region 6 protein, GTF2I, BAP135, WBSCR6 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GTF2I |
|---|---|
| Synonyms | BAP135, WBSCR6 |
| Function | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA- binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. |
| Cellular Location | Cytoplasm. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00484, ECO:0000269|PubMed:10373551} Note=Colocalizes with BTK in the cytoplasm |
| Tissue Location | Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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