癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-MYD88 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q99836 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB240 |
| Calculated MW | 33233 Da |
| Gene Name | MYD88 |
| Aliases | MYD88 Innate Immune Signal Transduction Adaptor; Myeloid Differentiation Primary Response Protein MyD88; Myeloid Differentiation Primary Response Gene (88); Myeloid Differentiation Primary Response 88; TLR Adaptor MYD88; Mutant Myeloid Differentiation Primary Response 88; MYD88D; IMD68; WM1 |
| Immunogen | A synthesized peptide derived from human MyD88 |
| Gene ID | 4615 |
|---|---|
| Other Names | Myeloid differentiation primary response protein MyD88, MYD88 (HGNC:7562) |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MYD88 (HGNC:7562) |
|---|---|
| Function | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575, PubMed:33718825, PubMed:37971847). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:19506249, PubMed:24316379, PubMed:40638072). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18- mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN- beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS- CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation (PubMed:33718825). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Ubiquitous.. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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