癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-NDUFA13 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q9P0J0 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB600 |
| Calculated MW | 16698 Da |
| Gene Name | NDUFA13 |
| Aliases | NADH:Ubiquinone Oxidoreductase Subunit A13; GRIM-19; GRIM19; CGI-39; CDA016; B16.6; Gene Associated With Retinoic And Interferon-Induced Mortality 19 Protein; Gene Associated With Retinoic And IFN-Induced Mortality 19 Protein; NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 13; NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 13; NADH-Ubiquinone Oxidoreductase B16.6 Subunit; Cell Death Regulatory Protein GRIM-19; Complex I B16.6 Subunit; Complex I-B16.6; CI-B16.6; Cell Death-Regulatory Protein GRIM19; MC1DN28 |
| Immunogen | A synthesized peptide derived from human GRIM19 |
| Gene ID | 51079 |
|---|---|
| Other Names | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, Cell death regulatory protein GRIM-19, Complex I-B16.6, CI-B16.6, Gene associated with retinoic and interferon-induced mortality 19 protein, GRIM-19, Gene associated with retinoic and IFN-induced mortality 19 protein, NADH-ubiquinone oxidoreductase B16.6 subunit, NDUFA13, GRIM19 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NDUFA13 |
|---|---|
| Synonyms | GRIM19 |
| Function | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091). |
| Cellular Location | Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus Note=Localizes mainly in the mitochondrion (PubMed:12628925). May be translocated into the nucleus upon IFN/RA treatment |
| Tissue Location | Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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