癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-PSIP1 / LEDGF Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O75475 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB840 |
| Calculated MW | 60103 Da |
| Gene Name | PSIP1 |
| Aliases | PC4 And SRSF1 Interacting Protein 1; LEDGF; DFS70; Lens Epithelium-Derived Growth Factor; PSIP2; P52; P75; PC4 And SFRS1 Interacting Protein 1; Dense Fine Speckles 70 KDa Protein; PC4 And SFRS1-Interacting Protein; CLL-Associated Antigen KW-7; PC4 And SFRS1 Interacting Protein 2; Transcriptional Coactivator P52/P75; Transcriptional Coactivator P75/P52; DFS 70; PAIP |
| Immunogen | A synthesized peptide derived from human PSIP1 / LEDGF |
| Gene ID | 11168 |
|---|---|
| Other Names | PC4 and SFRS1-interacting protein, CLL-associated antigen KW-7, Dense fine speckles 70 kDa protein, DFS 70, Lens epithelium-derived growth factor, Transcriptional coactivator p75/p52, PSIP1, DFS70, LEDGF, PSIP2 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PSIP1 |
|---|---|
| Synonyms | DFS70, LEDGF, PSIP2 |
| Function | Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre- mRNA splicing. Cellular cofactor for lentiviral integration. |
| Cellular Location | Nucleus. Note=Remains chromatin-associated throughout the cell cycle |
| Tissue Location | Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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