癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Peroxiredoxin 6 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P30041 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB910 |
| Calculated MW | 25035 Da |
| Gene Name | PRDX6 |
| Aliases | Peroxiredoxin 6; AiPLA2; NSGPx; AOP2; KIAA0106; 1-Cys; PRX; P29; Acidic Calcium-Independent Phospholipase A2; Lysophosphatidylcholine Acyltransferase 5; Glutathione-Dependent Peroxiredoxin; Non-Selenium Glutathione Peroxidase; Red Blood Cells Page Spot 12; Lyso-PC Acyltransferase 5; LPC Acyltransferase 5; Antioxidant Protein 2; Liver 2D Page Spot 40; 1-Cys Peroxiredoxin; Peroxiredoxin-6; 24 KDa Protein; 1-Cys PRX; MGC46173; LPCAT-5; Epididymis Secretory Sperm Binding Protein Li 128m; EC 1.11.1.27; EC 1.11.1.15; EC 2.3.1.23; HEL-S-128m; EC 3.1.1.4 |
| Immunogen | A synthesized peptide derived from human PRDX6 |
| Gene ID | 9588 |
|---|---|
| Other Names | Peroxiredoxin-6, 1.11.1.27, 1-Cys peroxiredoxin, 1-Cys PRX, 24 kDa protein, Acidic calcium-independent phospholipase A2, aiPLA2, 3.1.1.4, Antioxidant protein 2, Glutathione-dependent peroxiredoxin, Liver 2D page spot 40, Lysophosphatidylcholine acyltransferase 5, LPC acyltransferase 5, LPCAT-5, Lyso-PC acyltransferase 5, 2.3.1.23, Non-selenium glutathione peroxidase, NSGPx, Red blood cells page spot 12, PRDX6, AOP2, KIAA0106 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PRDX6 |
|---|---|
| Synonyms | AOP2, KIAA0106 |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (PubMed:10893423). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:10893423, PubMed:26830860). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (PubMed:10893423). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (PubMed:10893423). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3- phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero- 3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (PubMed:26830860). |
| Cellular Location | Cytoplasm. Lysosome {ECO:0000250|UniProtKB:O35244}. Note=Also found in lung secretory organelles (lamellar bodies). {ECO:0000250|UniProtKB:O35244} |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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