癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-RAD23A Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P54725 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1080 |
| Calculated MW | 39609 Da |
| Gene Name | RAD23A |
| Aliases | RAD23 Homolog A, Nucleotide Excision Repair Protein; HHR23A; UV Excision Repair Protein RAD23 Homolog A; RAD23, Yeast Homolog, A; MGC111083; HR23A; RAD23 (S. Cerevisiae) Homolog A; RAD23 Homolog A (S. Cerevisiae) |
| Immunogen | A synthesized peptide derived from human RAD23A |
| Gene ID | 5886 |
|---|---|
| Other Names | UV excision repair protein RAD23 homolog A, HR23A, hHR23A, RAD23A |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RAD23A (HGNC:9812) |
|---|---|
| Function | Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation, transcriptional regulation, and viral replication (PubMed:12643283, PubMed:14621999, PubMed:15321727, PubMed:20614012, PubMed:32209475, PubMed:9372924). Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3 (PubMed:32209475). Involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'- linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (PubMed:12643283, PubMed:14621999, PubMed:15321727). Involved in nucleotide excision repair, is considered functionally equivalent to RAD23B in global genome nucleotide excision repair (GG-NER) through its association with XPC. In vitro, the XPC-RAD23A complex demonstrates NER activity (PubMed:9372924). Can stabilize XPC (By similarity). |
| Cellular Location | Nucleus. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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