癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-PTBP1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | P26599 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1095 |
| Calculated MW | 59633 Da |
| Gene Name | PTBP1 |
| Aliases | Polypyrimidine Tract Binding Protein 1; Heterogeneous Nuclear Ribonucleoprotein I; HNRNP-I; HNRPI; PTB-1; PTB2; PTB3; PTB4; PPTB; PTB; Polypyrimidine Tract Binding Protein (Heterogeneous Nuclear Ribonucleoprotein I); Polypyrimidine Tract-Binding Protein 1; 57 KDa RNA-Binding Protein PPTB-1; HnRNP I; Heterogeneous Nuclear Ribonucleoprotein Polypeptide I; RNA-Binding Protein; HNRNPI; PTB-T |
| Immunogen | A synthesized peptide derived from human PTBP1 |
| Gene ID | 5725 |
|---|---|
| Other Names | Polypyrimidine tract-binding protein 1, PTB, 57 kDa RNA-binding protein PPTB-1, Heterogeneous nuclear ribonucleoprotein I, hnRNP I, PTBP1, PTB |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTBP1 |
|---|---|
| Synonyms | PTB |
| Function | Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre- mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre- mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9 (PubMed:14966131). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES- mediated translation (PubMed:21518806). |
| Cellular Location | Nucleus. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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