癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-PIK3C3 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q8NEB9 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1150 |
| Calculated MW | 101549 Da |
| Gene Name | PIK3C3 |
| Aliases | Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3; HVps34; Vps34; Phosphatidylinositol 3-Kinase P100 Subunit; Vacuolar Protein Sorting 34 Homolog; Phosphoinositide-3-Kinase, Class 3; PtdIns-3-Kinase Type 3; PI3-Kinase Type 3; EC 2.7.1.137; PI3K Type 3; Phosphatidylinositol 3-Kinase, Catalytic Subunit Type 3; Phosphoinositide-3-Kinase Class 3; EC 2.7.1; VPS34 |
| Immunogen | A synthesized peptide derived from human PI 3 Kinase Class 3 |
| Gene ID | 5289 |
|---|---|
| Other Names | Phosphatidylinositol 3-kinase catalytic subunit type 3, PI3-kinase type 3, PI3K type 3, PtdIns-3-kinase type 3, 2.7.1.137, Phosphatidylinositol 3-kinase p100 subunit, Phosphoinositide-3-kinase class 3, hVps34, PIK3C3 (HGNC:8974), VPS34 {ECO:0000305} |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PIK3C3 (HGNC:8974) |
|---|---|
| Synonyms | VPS34 {ECO:0000305} |
| Function | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:14617358, PubMed:33637724, PubMed:7628435, PubMed:33993848). As part of PI3KC3- C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding (PubMed:32690950). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20208530, PubMed:20643123). Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). |
| Cellular Location | Midbody. Late endosome. Cytoplasmic vesicle, autophagosome. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358). Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity) {ECO:0000250|UniProtKB:Q6PF93, ECO:0000305|PubMed:14617358} |
| Tissue Location | Ubiquitously expressed, with a highest expression in skeletal muscle. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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