癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-RBBP4 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q09028 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1240 |
| Calculated MW | 47656 Da |
| Gene Name | RBBP4 |
| Aliases | RB Binding Protein 4, Chromatin Remodeling Factor; Retinoblastoma-Binding Protein 4; RbAp48; NURF55; Lin-53; Nucleosome-Remodeling Factor Subunit RBAP48; Chromatin Assembly Factor I P48 Subunit; Chromatin Assembly Factor 1 Subunit C; Retinoblastoma-Binding Protein P48; Histone-Binding Protein RBBP4; CAF-I 48 KDa Subunit; CAF-1 Subunit C; CAF-I P48; RBBP-4; Chromatin Assembly Factor/CAF-1 P48 Subunit; Retinoblastoma Binding Protein 4; MSI1 Protein Homolog; RBAP48 |
| Immunogen | A synthesized peptide derived from human RbAp48 |
| Gene ID | 5928 |
|---|---|
| Other Names | Histone-binding protein RBBP4, Chromatin assembly factor 1 subunit C, CAF-1 subunit C, Chromatin assembly factor I p48 subunit, CAF-I 48 kDa subunit, CAF-I p48, Nucleosome-remodeling factor subunit RBAP48, Retinoblastoma-binding protein 4, RBBP-4, Retinoblastoma-binding protein p48, RBBP4, RBAP48 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RBBP4 |
|---|---|
| Synonyms | RBAP48 |
| Function | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:16428440, PubMed:28977666, PubMed:39460621). Component of the PRC2 complex, which promotes repression of homeotic genes during development (PubMed:29499137, PubMed:31959557). Component of the NURF (nucleosome remodeling factor) complex (PubMed:14609955, PubMed:15310751). |
| Cellular Location | Nucleus. Chromosome, telomere. Note=Localizes to chromatin as part of the PRC2 complex. |
| Tissue Location | Expressed in neuroblastoma cells. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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