癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Plexin A1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9UIW2 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1245 |
| Calculated MW | 211067 Da |
| Gene Name | PLXNA1 |
| Aliases | PLXNA1; Plexin A1; NOV; PLXN1; Semaphorin Receptor NOV; PLEXIN-A1; Plexin-A1; Plexin 1; DWOPNED; NOVP |
| Immunogen | A synthesized peptide derived from human Plexin A1 |
| Gene ID | 5361 |
|---|---|
| Other Names | Plexin-A1, Semaphorin receptor NOV, PLXNA1 (HGNC:9099), NOV, PLXN1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PLXNA1 (HGNC:9099) |
|---|---|
| Synonyms | NOV, PLXN1 |
| Function | Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P70206}; Single-pass type I membrane protein |
| Tissue Location | Detected in fetal brain, lung, liver and kidney. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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