癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-NHERF1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | O14745 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1270 |
| Calculated MW | 38868 Da |
| Gene Name | NHERF1 |
| Aliases | NHERF1; NHERF Family PDZ Scaffold Protein 1; NHERF-1; NHERF; EBP50; SLC9A3R1; NHE-RF; Solute Carrier Family 9, Subfamily A (NHE3, Cation Proton Antiporter 3), Member 3 Regulator 1; Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF1; Ezrin-Radixin-Moesin-Binding Phosphoprotein 50; Regulatory Cofactor Of Na(+)/H(+) Exchanger; Na(+)/H(+) Exchange Regulatory Cofactor 1; SLC9A3 Regulator 1; Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 3 Regulatory Factor 1; Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 3 Regulator 1; Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 3 Regulator 1; Solute Carrier Family 9 Isoform A3 Regulatory Factor 1; Ezrin-Radixin-Moesin Binding Phosphoprotein-50; Sodium-Hydrogen Exchanger Regulatory Factor 1; Na+/H+ Exchange Regulatory Co-Factor; NPHLOP2 |
| Immunogen | A synthesized peptide derived from human EBP50 |
| Gene ID | 9368 |
|---|---|
| Other Names | Na(+)/H(+) exchange regulatory cofactor NHE-RF1, NHERF-1, Ezrin-radixin-moesin-binding phosphoprotein 50, EBP50, Regulatory cofactor of Na(+)/H(+) exchanger, Sodium-hydrogen exchanger regulatory factor 1, Solute carrier family 9 isoform A3 regulatory factor 1, NHERF1 (HGNC:11075), NHERF, SLC9A3R1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NHERF1 (HGNC:11075) |
|---|---|
| Synonyms | NHERF, SLC9A3R1 |
| Function | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. |
| Cellular Location | Cytoplasm. Apical cell membrane. Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Note=Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T-cells. |
| Tissue Location | Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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