癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Prostaglandin E Synthase 3 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | Q15185 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1470 |
| Calculated MW | 18697 Da |
| Gene Name | PTGES3 |
| Aliases | PTGES3; Prostaglandin E Synthase 3; CPGES; TEBP; P23; Prostaglandin E Synthase 3 (Cytosolic); Cytosolic Prostaglandin E2 Synthase; Progesterone Receptor Complex P23; Telomerase-Binding Protein P23; Hsp90 Co-Chaperone; EC 5.3.99.3; Unactive Progesterone Receptor, 23 KD; Cytosolic Prostaglandin E Synthase |
| Immunogen | A synthesized peptide derived from human p23 |
| Gene ID | 10728 |
|---|---|
| Other Names | Prostaglandin E synthase 3, 5.3.99.3, Cytosolic prostaglandin E2 synthase, cPGES, Hsp90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, PTGES3, P23, TEBP |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTGES3 |
|---|---|
| Synonyms | P23, TEBP |
| Function | Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q3ZBF7}. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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