癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-DNA Polymerase beta Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P06746 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1475 |
| Calculated MW | 38178 Da |
| Gene Name | POLB |
| Aliases | POLB; DNA Polymerase Beta; Polymerase (DNA Directed), Beta; 5'-Deoxyribose-Phosphate Lyase; Polymerase (DNA) Beta; 5'-DRP Lyase; AP Lyase; DNA Polymerase Beta Subunit; DNA Pol Beta; EC 4.2.99.18; EC 4.2.99.-; EC 2.7.7.7 |
| Immunogen | A synthesized peptide derived from human DNA polymerase beta |
| Gene ID | 5423 |
|---|---|
| Other Names | DNA polymerase beta, 2.7.7.7, 5'-deoxyribose-phosphate lyase, 5'-dRP lyase, 4.2.99.-, AP lyase, 4.2.99.18, POLB |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | POLB |
|---|---|
| Function | Repair polymerase that plays a key role in base-excision repair (PubMed:10556592, PubMed:9207062, PubMed:9572863). During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap (PubMed:10556592, PubMed:17526740, PubMed:8841119, PubMed:9556598, PubMed:9572863, PubMed:9614142). Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase (PubMed:9614142). |
| Cellular Location | Nucleus. Cytoplasm. Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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