癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-PTTG1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | O95997 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB1495 |
| Calculated MW | 22024 Da |
| Gene Name | PTTG1 |
| Aliases | PTTG1 Regulator Of Sister Chromatid Separation, Securin; Securin; HPTTG; PTTG; EAP1; Tumor-Transforming Protein ; ECRAR; TUTR1; Endogenous Cardiac Regeneration-Associated Regulator; Pituitary Tumor-Transforming Gene 1 Protein; Pituitary Tumor-Transforming 1; ESP1-Associated Protein 1; Esp1-Associated Protein |
| Immunogen | A synthesized peptide derived from human Securin |
| Gene ID | 9232 |
|---|---|
| Other Names | Securin, Esp1-associated protein, Pituitary tumor-transforming gene 1 protein, Tumor-transforming protein 1, hPTTG, PTTG1, EAP1, PTTG, TUTR1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTTG1 |
|---|---|
| Synonyms | EAP1, PTTG, TUTR1 |
| Function | Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. |
| Cellular Location | Cytoplasm. Nucleus. |
| Tissue Location | Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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