癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-TNF Receptor Associated Protein 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q12931 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB2560 |
| Calculated MW | 80110 Da |
| Gene Name | TRAP1 |
| Aliases | TRAP1; TNF Receptor Associated Protein 1; HSP75; HSP90L; Tumor Necrosis Factor Type 1 Receptor-Associated Protein; Heat Shock Protein 75 KDa, Mitochondrial; TNFR-Associated Protein 1; HSP 75; TRAP-1; TNF Receptor-Associated Protein 1; Testicular Tissue Protein Li 209 |
| Immunogen | A synthesized peptide derived from human TRAP1 |
| Gene ID | 10131 |
|---|---|
| Other Names | Heat shock protein 75 kDa, mitochondrial, HSP 75, Heat shock protein family C member 5, TNFR-associated protein 1, Tumor necrosis factor type 1 receptor-associated protein, TRAP-1, TRAP1, HSP75, HSPC5 {ECO:0000303|PubMed:18663603} |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TRAP1 |
|---|---|
| Synonyms | HSP75, HSPC5 {ECO:0000303|PubMed:1866360 |
| Function | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. |
| Cellular Location | Mitochondrion. Mitochondrion inner membrane Mitochondrion matrix |
| Tissue Location | Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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