癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-VAMP Associated Protein A Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q9P0L0 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB2580 |
| Calculated MW | 27893 Da |
| Gene Name | VAPA |
| Aliases | VAPA; VAMP Associated Protein A; VAP-A; HVAP-33; VAMP (Vesicle-Associated Membrane Protein)-Associated Protein A, 33kDa; Vesicle-Associated Membrane Protein-Associated Protein A; 33 KDa VAMP-Associated Protein; VAMP-A; VAP-33; VAP33; VAMP (Vesicle-Associated Membrane Protein)-Associated Protein A (33kD); Epididymis Secretory Sperm Binding Protein; VAMP-Associated Protein A |
| Immunogen | A synthesized peptide derived from human VAPA |
| Gene ID | 9218 |
|---|---|
| Other Names | Vesicle-associated membrane protein-associated protein A, VAMP-A, VAMP-associated protein A, VAP-A, 33 kDa VAMP-associated protein {ECO:0000303|Ref.2}, VAP-33, VAPA (HGNC:12648), VAP33 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | VAPA (HGNC:12648) |
|---|---|
| Synonyms | VAP33 |
| Function | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44 (PubMed:32344433, PubMed:33124732). STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes (PubMed:33124732). Via interaction with WDR44 participates in neosynthesized protein export (PubMed:32344433). In addition, recruited to the plasma membrane through OSBPL3 binding (PubMed:25447204). The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204). With OSBPL3, may regulate ER morphology (PubMed:16143324). May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass type IV membrane protein. Cell junction, tight junction. Nucleus membrane {ECO:0000250|UniProtKB:Q9Z270}. Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells. |
| Tissue Location | Ubiquitous. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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