癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-JUN Rabbit Polyclonal Antibody
Rabbit polyclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P05412 |
| Reactivity | Human |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35676 Da |
| Gene Name | JUN |
| Aliases | JUN; Jun Proto-Oncogene, AP-1 Transcription Factor Subunit; V-Jun Avian Sarcoma Virus 17 Oncogene Homolog 2; C-Jun; AP-1; Transcription Factor AP-1 Subunit Jun; Transcription Factor Jun; Proto-Oncogene C-Jun; Activator Protein 1; Jun Oncogene; AP1; P39; V-Jun Sarcoma Virus 17 Oncogene Homolog; Jun Activation Domain Binding Protein; Enhancer-Binding Protein AP1; Transcription Factor AP-1; Proto-Oncogene CJun; CJUN |
| Immunogen | A synthesized peptide derived from human c-Jun |
| Gene ID | 3725 |
|---|---|
| Other Names | Transcription factor Jun, Activator protein 1, AP1, Proto-oncogene c-Jun, Transcription factor AP-1 subunit Jun, V-jun avian sarcoma virus 17 oncogene homolog, p39, JUN |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | JUN |
|---|---|
| Function | Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in the developing and adult prostate and prostate cancer cells. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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