癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-NK2 Homeobox 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | P43699 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB5440 |
| Calculated MW | 38596 Da |
| Gene Name | NKX2-1 |
| Aliases | NKX2-1; NK2 Homeobox 1; TTF-1; TTF1; Thyroid Transcription Factor 1; NKX2A; TITF1; Thyroid-Specific Enhancer-Binding Protein; Homeobox Protein NK-2 Homolog A; Homeobox Protein Nkx-2.1; Thyroid Nuclear Factor 1; T/EBP; BCH; NK-2 Homolog A; Benign Chorea; NKX2.1; NMTC1; NK-2; TEBP; BHC |
| Immunogen | A synthesized peptide derived from human TTF1 |
| Gene ID | 7080 |
|---|---|
| Other Names | Homeobox protein Nkx-2.1, Homeobox protein NK-2 homolog A, Thyroid nuclear factor 1, Thyroid transcription factor 1, TTF-1, Thyroid-specific enhancer-binding protein, T/EBP, NKX2-1 (HGNC:11825), NKX2A, TITF1, TTF1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NKX2-1 (HGNC:11825) |
|---|---|
| Synonyms | NKX2A, TITF1, TTF1 |
| Function | Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:P50220}. |
| Tissue Location | Thyroid and lung. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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