癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-ATG4C Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | Q96DT6 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6165 |
| Calculated MW | 52497 Da |
| Gene Name | ATG4C |
| Aliases | ATG4C; Autophagy Related 4C Cysteine Peptidase; AUTL3; APG4C; AUTL1; Autophagy-Related Cysteine Endopeptidase 3; Autophagy-Related Protein 4 Homolog C; AUT-Like 3 Cysteine Endopeptidase; Cysteine Protease ATG4C; Autophagin-3; FLJ14867; HsAPG4C; AUT (S. Cerevisiae)-Like 1, Cysteine Endopeptidase; AUT-Like 1, Cysteine Endopeptidase (S. Cerevisiae); ATG4 Autophagy Related 4 Homolog C (S. Cerevisiae); APG4 Autophagy 4 Homolog C (S. Cerevisiae); Epididymis Secretory Sperm Binding Protein; Autophagy Related 4C, Cysteine Peptidase; ATG4 Autophagy Related 4 Homolog C; AUT-Like 1, Cysteine; Endopeptidase; APG4 Autophagy 4 Homolog C; EC 3.4.22.-; EC 3.4.22; APG4-C |
| Immunogen | Recombinant protein of human ATG4C |
| Gene ID | 84938 |
|---|---|
| Other Names | Cysteine protease ATG4C, 3.4.22.-, AUT-like 3 cysteine endopeptidase, Autophagy-related cysteine endopeptidase 3, Autophagin-3, Autophagy-related protein 4 homolog C, HsAPG4C, ATG4C {ECO:0000303|PubMed:21177865, ECO:0000312|HGNC:HGNC:16040} |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ATG4C {ECO:0000303|PubMed:21177865, ECO:0000312|HGNC:HGNC:16040} |
|---|---|
| Function | Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins (PubMed:21177865, PubMed:29458288, PubMed:30661429). The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (PubMed:21177865). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins (PubMed:29458288, PubMed:33909989). Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy (PubMed:29458288, PubMed:33909989). Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity (PubMed:29458288). In contrast to other members of the family, weakly or not involved in phagophore growth during mitophagy (PubMed:33773106). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8BGE6}. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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