癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-NIMA Related Kinase 9 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q8TD19 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB6355 |
| Calculated MW | 107168 Da |
| Gene Name | NEK9 |
| Aliases | NEK9; NIMA Related Kinase 9; NERCC; NERCC1; Nek8; NIMA (Never In Mitosis Gene A)- Related Kinase 9; Serine/Threonine-Protein Kinase Nek9; NimA-Related Protein Kinase 9; DKFZp434D0935; Nercc1 Kinase; EC 2.7.11.1; MGC16714 2 5Never In Mitosis A-Related Kinase 9; NimA-Related Kinase 8; KIAA1995; LCCS10; APUG; NEK8; NC |
| Immunogen | Recombinant protein of human NEK9 |
| Gene ID | 91754 |
|---|---|
| Other Names | Serine/threonine-protein kinase Nek9, 2.7.11.1, Nercc1 kinase, Never in mitosis A-related kinase 9, NimA-related protein kinase 9, NimA-related kinase 8, Nek8, NEK9 {ECO:0000303|PubMed:12840024, ECO:0000312|HGNC:HGNC:18591} |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NEK9 {ECO:0000303|PubMed:12840024, ECO:0000312|HGNC:HGNC:18591} |
|---|---|
| Function | Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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