癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-OTUB1 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q96FW1 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2b |
| Clone Names | 24GB6485 |
| Calculated MW | 31284 Da |
| Gene Name | OTUB1 |
| Aliases | OTUB1; OTU Deubiquitinase, Ubiquitin Aldehyde Binding 1; OTU Domain-Containing Ubiquitin Aldehyde-Binding Protein 1; Ubiquitin-Specific-Processing Protease OTUB1; OTU Domain, Ubiquitin Aldehyde Binding 1; Deubiquitinating Enzyme OTUB1; Ubiquitin Thioesterase OTUB1; Otubain-1; FLJ20113; FLJ40710; OTB1; OTU1; Ubiquitin-Specific Protease Otubain 1; OTU-Domain Ubal-Binding 1; EC 3.4.19.12; EC 3.1.2; HSPC263; HOTU1 |
| Immunogen | Recombinant protein of human OTUB1 |
| Gene ID | 55611 |
|---|---|
| Other Names | Ubiquitin thioesterase OTUB1, 3.4.19.12, Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, hOTU1, Ubiquitin-specific-processing protease OTUB1, OTUB1, OTB1, OTU1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OTUB1 |
|---|---|
| Synonyms | OTB1, OTU1 |
| Function | Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation (PubMed:12401499, PubMed:12704427, PubMed:14661020, PubMed:23827681). Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen (PubMed:14661020). Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy (PubMed:14661020). Isoform 1 destabilizes RNF128, leading to prevent anergy (PubMed:14661020). In contrast, isoform 2 stabilizes RNF128 and promotes anergy (PubMed:14661020). Surprisingly, it regulates RNF128- mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128 (PubMed:14661020). Deubiquitinates estrogen receptor alpha (ESR1) (PubMed:19383985). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains (PubMed:18954305, PubMed:19211026, PubMed:23827681). Not able to cleave di-ubiquitin (PubMed:18954305, PubMed:23827681). Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to 'Lys-48'-linked ubiquitin (PubMed:18954305, PubMed:23827681). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:B2RYG6}. |
| Tissue Location | Isoform 1 is ubiquitous. Isoform 2 is expressed only in lymphoid tissues such as tonsils, lymph nodes and spleen, as well as peripheral blood mononuclear cells |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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