癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Chromogranin A Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, ICC |
|---|---|
| Primary Accession | P10645 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB6520 |
| Calculated MW | 50688 Da |
| Gene Name | CHGA |
| Aliases | CHGA; Chromogranin A; PHE5; PHES; PaRathyroid Secretory Protein 1; Pituitary Secretory Protein I; Chromogranin-A; SP-I; Betagranin (N-Terminal Fragment Of Chromogranin A); Pancreastatin; Chromofungin; Vasostatin; Parastatin; Catestatin; CGA; CgA |
| Immunogen | Recombinant protein of human CHGA |
| Gene ID | 1113 |
|---|---|
| Other Names | Chromogranin-A, CgA, Pituitary secretory protein I, SP-I, Vasostatin-1, Vasostatin I, Vasostatin-2, Vasostatin II, EA-92, ES-43, Pancreastatin, SS-18, WA-8, WE-14, LF-19, Catestatin, SL21, AL-11, GV-19, GR-44, ER-37, GE-25, Serpinin-RRG, Serpinin, p-Glu serpinin precursor, CHGA |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CHGA |
|---|---|
| Function | [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. |
| Cellular Location | [Serpinin]: Secreted {ECO:0000250|UniProtKB:P26339}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P26339}. Note=Pyroglutaminated serpinin localizes to secretory vesicle. {ECO:0000250|UniProtKB:P26339} |
| Tissue Location | Detected in cerebrospinal fluid (at protein level) (PubMed:25326458). Detected in urine (at protein level) (PubMed:37453717). |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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