癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-SERPINB1 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | P30740 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB6545 |
| Calculated MW | 42742 Da |
| Gene Name | SERPINB1 |
| Aliases | SERPINB1; Serpin Family B Member 1; MNEI; PI2; LEI; EI; Leukocyte Elastase Inhibitor; ELANH2; Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 1; Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 1; Monocyte/Neutrophil Elastase Inhibitor; Peptidase Inhibitor; M/NEI; PI-2; Protease Inhibitor 2 (Anti-Elastase), Monocyte/Neutrophil Derived; Epididymis Secretory Protein Li 27; Epididymis Luminal Protein 57; Anti-Elastase; Serpin B1; HEL-S-27; HEL57 |
| Immunogen | Recombinant protein of human SERPINB1 |
| Gene ID | 1992 |
|---|---|
| Other Names | Leukocyte elastase inhibitor, LEI, Monocyte/neutrophil elastase inhibitor, EI, M/NEI, Peptidase inhibitor 2, PI-2, Serpin B1, SERPINB1, ELANH2, MNEI, PI2 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SERPINB1 |
|---|---|
| Synonyms | ELANH2, MNEI, PI2 |
| Function | Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651). |
| Cellular Location | Secreted. Cytoplasm. Cytolytic granule. Early endosome |
| Tissue Location | In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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