癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-DNAJB1 mouse monoclonal antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P25685 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2b |
| Clone Names | 24GB6700 |
| Calculated MW | 38044 Da |
| Gene Name | DNAJB1 |
| Aliases | DNAJB1; DnaJ Heat Shock Protein Family (Hsp40) Member B1; RSPH16B; Hsp40; HSPF1; Sis1; DnaJ (Hsp40) Homolog, Subfamily B, Member 1; DnaJ Homolog Subfamily B Member 1; Heat Shock 40 KDa Protein 1; DnaJ Protein Homolog 1; Human DnaJ Protein 1; Radial Spoke 16 Homolog B (Chlamydomonas); Radial Spoke 16 Homolog B; Heat Shock Protein 40; DNAJ1; HSP40; HDj-1; Hdj1; HDJ1 |
| Immunogen | Recombinant protein of human DNAJB1 |
| Gene ID | 3337 |
|---|---|
| Other Names | DnaJ homolog subfamily B member 1, DnaJ protein homolog 1, Heat shock 40 kDa protein 1, HSP40, Heat shock protein 40, Human DnaJ protein 1, hDj-1, DNAJB1, DNAJ1, HDJ1, HSPF1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DNAJB1 |
|---|---|
| Synonyms | DNAJ1, HDJ1, HSPF1 |
| Function | Interacts with HSP70 and can stimulate its ATPase activity. Acts also with TTC1 as a chaperone adapter that regulates HSP70- dependent folding process by interacting with the HSP70 amino terminal region (PubMed:14503850). Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). |
| Cellular Location | Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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