癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-AKR1B1 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | P15121 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB6775 |
| Calculated MW | 35853 Da |
| Gene Name | AKR1B1 |
| Aliases | AKR1B1; Aldo-Keto Reductase Family 1 Member B; AR; Aldose Reductase; ALDR1; Aldo-Keto Reductase Family 1 Member B1; EC 1.1.1.21; ALR2; Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase); Lii5-2 CTCL Tumor Antigen; Low Km Aldose Reductase; Aldehyde Reductase 1; Aldehyde Reductase; EC 1.1.1.300; EC 1.1.1.372; EC 1.1.1.54; EC 1.1.1; ADR |
| Immunogen | Recombinant protein of human AKR1B1 |
| Gene ID | 231 |
|---|---|
| Other Names | Aldo-keto reductase family 1 member B1, 1.1.1.21, 1.1.1.300, 1.1.1.372, 1.1.1.54, Aldehyde reductase, Aldose reductase, AR, AKR1B1, ALDR1, ALR2 {ECO:0000303|PubMed:17368668} |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | AKR1B1 |
|---|---|
| Synonyms | ALDR1, ALR2 {ECO:0000303|PubMed:17368668 |
| Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids and xenobiotics substrates (PubMed:10510318, PubMed:12732097, PubMed:1332968, PubMed:21329684, PubMed:8245005, PubMed:4402695, PubMed:1936586). It catalyzes the reduction of glucose to sorbitol, the first step of the polyol pathway, an alternative route of glucose metabolism that converts glucose to fructose (PubMed:4402695, PubMed:1936586). This pathway becomes highly active under elevated glucose levels, such as during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2- (5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS- carbonyls) (PubMed:21329684). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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