癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-G-rich RNA sequence binding factor 1 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q12849 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 1890 |
| Calculated MW | 53126 Da |
| Gene Name | GRSF1 |
| Aliases | GRSF1; G-Rich RNA Sequence Binding Factor 1; G-Rich Sequence Factor 1; GRSF-1 |
| Immunogen | A synthesized peptide derived from human GRSF1 |
| Gene ID | 2926 |
|---|---|
| Other Names | G-rich sequence factor 1, GRSF-1, GRSF1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GRSF1 |
|---|---|
| Function | Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G- rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non- coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT- ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381). |
| Cellular Location | [Isoform 1]: Mitochondrion matrix Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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