癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Clathrin Heavy Chain Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | Q00610 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 24GB6960 |
| Calculated MW | 191615 Da |
| Gene Name | CLTC |
| Aliases | CLTC; Clathrin Heavy Chain; CLTCL; Hc; Clathrin Heavy Chain On Chromosome 17; Clathrin, Heavy Polypeptide-Like 2; Clathrin, Heavy Polypeptide (Hc); Clathrin Heavy Chain 1; CLH-17; Clathrin, Heavy Chain (Hc); Clathrin, Heavy Chain; KIAA0034; CHC17; MRD56; CLH17; CHC |
| Immunogen | A synthesized peptide derived from human Clathrin heavy chain |
| Gene ID | 1213 |
|---|---|
| Other Names | Clathrin heavy chain 1, Clathrin heavy chain on chromosome 17, CLH-17, CLH1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CLH1 |
|---|---|
| Function | Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:16968737, PubMed:21297582). The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Plays a role in early autophagosome formation (PubMed:20639872). Interaction with DNAJC6 mediates the recruitment of HSPA8 to the clathrin lattice and creates local destabilization of the lattice promoting uncoating (By similarity). |
| Cellular Location | Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Melanosome. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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