癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-CNDP2 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q96KP4 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB7930 |
| Calculated MW | 52878 Da |
| Gene Name | CNDP2 |
| Aliases | CNDP2; Carnosine Dipeptidase 2; CPGL; CN2; Peptidase A; HsT2298; PEPA; CNDP Dipeptidase 2 (Metallopeptidase M20 Family); Glutamate Carboxypeptidase-Like Protein 1; Cytosolic Non-Specific Dipeptidase; Cytosolic Nonspecific Dipeptidase; Carnosine Dipeptidase II; Threonyl Dipeptidase; Carnosinase-2; FLJ10830; HEL-S-13; Epididymis Secretory Protein Li 13; CNDP Dipeptidase; EC 3.4.13.18 |
| Immunogen | Recombinant protein of human CNDP2 |
| Gene ID | 55748 |
|---|---|
| Other Names | Cytosolic non-specific dipeptidase, 3.4.13.18, CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, Threonyl dipeptidase, CNDP2 {ECO:0000303|PubMed:25964343, ECO:0000312|HGNC:HGNC:24437} |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CNDP2 {ECO:0000303|PubMed:25964343, ECO:0000312|HGNC:HGNC:24437} |
|---|---|
| Function | Cytosolic metallodipeptidase with broad substrate specificity that catalyzes the hydrolysis of amide bonds in dipeptides and pseudopeptides (PubMed:12473676, PubMed:19346245, PubMed:25964343). Substrates include L-cysteinylglycine, an intermediate metabolite of the gamma-glutamyl cycle of glutathione metabolism (PubMed:19346245, PubMed:25964343). Can also hydrolyze threonyl-containing dipeptides (By similarity). Upon physiological conditions of amino acids and lactate excess can also catalyze a reverse proteolysis reaction, generating N- [(S)-lactoyl]-L-phenylalanine and possibly other N-lactoyl-amino acids which it can also hydrolyze in vitro. N-[(S)-lactoyl]-L-phenylalanine is an exercise-induced metabolite that influences food intake and systemic energy balance (PubMed:25964343). Carnosine is probably not a physiological substrate and L-homocarnosine is not a substrate for this enzyme (PubMed:12473676). Plays a role in the regulation of cell cycle arrest and apoptosis (PubMed:17121880, PubMed:24395568). |
| Cellular Location | Cytoplasm, cytosol |
| Tissue Location | [Isoform 1]: Ubiquitously expressed with higher levels in kidney and liver (at protein level). Expressed in peripheral blood leukocytes (PubMed:12473676). Expressed in gastric mucosa and down-regulated in gastric cancer mucosal tissues (at protein level) (PubMed:24395568). |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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