癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-Purified ARIH2 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O95376 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB8000 |
| Calculated MW | 57819 Da |
| Gene Name | ARIH2 |
| Aliases | ARIH2; Ariadne RBR E3 Ubiquitin Protein Ligase 2; TRIAD1; All-Trans Retinoic Acid Inducible RING Finger; RING-Type E3 Ubiquitin Transferase ARIH2; E3 Ubiquitin-Protein Ligase ARIH2; Protein Ariadne-2 Homolog; ARI2; Ariadne (Drosophila) Homolog 2; Ariadne Homolog 2 (Drosophila); Ariadne Homolog 2; Triad1 Protein; EC 2.3.2.31; ARI-2 |
| Immunogen | Recombinant protein of human ARIH2 |
| Gene ID | 10425 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase ARIH2, ARI-2, Protein ariadne-2 homolog, 2.3.2.31, Triad1 protein, ARIH2 {ECO:0000303|PubMed:31253590, ECO:0000312|HGNC:HGNC:690} |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ARIH2 {ECO:0000303|PubMed:31253590, ECO:0000312|HGNC:HGNC:690} |
|---|---|
| Function | E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655, PubMed:33268465, PubMed:34518685, PubMed:38418882). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (PubMed:33268465, PubMed:34518685, PubMed:38418882). The initial ubiquitin is then elongated (PubMed:33268465). E3 ubiquitin- protein ligase activity is activated upon binding to neddylated form of the cullin-5 (CUL5) component of the ECS complex (PubMed:24076655). Together with the ECS(ASB9) complex, catalyzes ubiquitination of CKB (PubMed:33268465). Promotes ubiquitination of DCUN1D1 (PubMed:30587576). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). |
| Cellular Location | Nucleus. Cytoplasm |
| Tissue Location | Widely expressed with higher expression in granulocytes. |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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