癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-DYNC1LI1 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9Y6G9 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2b |
| Clone Names | 24GB8115 |
| Calculated MW | 56579 Da |
| Gene Name | DYNC1LI1 |
| Aliases | DYNC1LI1; Dynein Cytoplasmic 1 Light Intermediate Chain 1; DNCLI1; Dynein, Cytoplasmic, Light Intermediate Polypeptide 1; Cytoplasmic Dynein 1 Light Intermediate Chain 1; Dynein Light Intermediate Chain 1, Cytosolic 3; Dynein Light Chain A; DLIC-1; DLC-A; LIC1 |
| Immunogen | Recombinant protein of human DYNC1LI1 |
| Gene ID | 51143 |
|---|---|
| Other Names | Cytoplasmic dynein 1 light intermediate chain 1, LIC1, Dynein light chain A, DLC-A, Dynein light intermediate chain 1, cytosolic, DLIC-1, DYNC1LI1, DNCLI1 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DYNC1LI1 |
|---|---|
| Synonyms | DNCLI1 |
| Function | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Forms a functional Rab11/RAB11FIP3/dynein complex onto endosomal membrane that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC) (PubMed:20026645). |
| Cellular Location | Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Recycling endosome membrane. Note=During interphase, localized in vesicles continuously moving from peripheral sorting endosomes in the cell towards the pericentrosomal endosomal recycling compartment (ERC) |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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