癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-EIF4E2 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | O60573 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB8140 |
| Calculated MW | 28362 Da |
| Gene Name | EIF4E2 |
| Aliases | EIF4E2; Eukaryotic Translation Initiation Factor 4E Family Member 2; Eukaryotic Translation Initiation Factor 4E-Like 3; EIF4EL3; IF4e; 4EHP; Eukaryotic Translation Initiation Factor 4E Homologous Protein; Eukaryotic Translation Initiation Factor 4E Type 2; MRNA Cap-Binding Protein Type 3; EIF4E-Like Protein 4E-LP; EIF-4E Type 2; H4EHP; EIF4E-Like Cap-Binding Protein; MRNA Cap-Binding Protein 4EHP; EIF4E Type 2; 4E-LP |
| Immunogen | Recombinant protein of human EIF4E2 |
| Gene ID | 9470 |
|---|---|
| Other Names | Eukaryotic translation initiation factor 4E type 2, eIF-4E type 2, eIF4E type 2, Eukaryotic translation initiation factor 4E homologous protein, Eukaryotic translation initiation factor 4E-like 3, eIF4E-like protein 4E-LP, mRNA cap-binding protein 4EHP, h4EHP, mRNA cap-binding protein type 3, EIF4E2 {ECO:0000303|PubMed:15153109, ECO:0000312|HGNC:HGNC:3293} |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | EIF4E2 {ECO:0000303|PubMed:15153109, ECO:0000312|HGNC:HGNC:3293} |
|---|---|
| Function | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation (PubMed:17368478, PubMed:22751931, PubMed:25624349, PubMed:33581076, PubMed:9582349). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). In P-bodies, component of a complex that promotes miRNA-mediated translational repression (PubMed:28487484). Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism (PubMed:28487484, PubMed:33581076). |
| Cellular Location | Cytoplasm. Cytoplasm, P-body |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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