癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-DPP9 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | Q86TI2 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG2b |
| Clone Names | 24GB8170 |
| Calculated MW | 98263 Da |
| Gene Name | DPP9 |
| Aliases | DPP9; Dipeptidyl Peptidase 9; Dipeptidyl Peptidase-Like Protein 9; Dipeptidyl Peptidase IX; DPP IX; DPRP-2; DPLP9; DPRP2; DP9; Dipeptidyl Peptidase IV-Related Protein-2; Dipeptidyl Peptidase IV-Related Protein 2; Dipeptidylpeptidase 9; EC 3.4.14.5; IMD111; HATIS |
| Immunogen | Recombinant protein of human DPP9 |
| Gene ID | 91039 |
|---|---|
| Other Names | Dipeptidyl peptidase 9, DP9, 3.4.14.5, Dipeptidyl peptidase IV-related protein 2, DPRP-2, Dipeptidyl peptidase IX, DPP IX, Dipeptidyl peptidase-like protein 9, DPLP9, DPP9 {ECO:0000303|PubMed:12459266, ECO:0000312|HGNC:HGNC:18648} |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DPP9 {ECO:0000303|PubMed:12459266, ECO:0000312|HGNC:HGNC:18648} |
|---|---|
| Function | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2 (PubMed:12662155, PubMed:16475979, PubMed:19667070, PubMed:29382749, PubMed:30291141, PubMed:33731929, PubMed:36112693). Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8 (PubMed:27820798, PubMed:29967349, PubMed:30291141, PubMed:31525884, PubMed:32796818, PubMed:36112693, PubMed:36357533). Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation (PubMed:33731929, PubMed:33731932, PubMed:34019797). The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8; however, neither NLRP1 nor CARD8 are bona fide substrates of DPP9, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition (PubMed:33731929). |
| Cellular Location | [Isoform 1]: Cytoplasm, cytosol |
| Tissue Location | Ubiquitously expressed, with highest levels in liver, heart and muscle, and lowest levels in brain |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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