癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KD-Validated Anti-EXOSC1 Mouse Monoclonal Antibody
Mouse monoclonal antibody
- 产品详情
- 实验流程
Application 
| WB, FC |
|---|---|
| Primary Accession | Q9Y3B2 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 24GB8290 |
| Calculated MW | 21452 Da |
| Gene Name | EXOSC1 |
| Aliases | EXOSC1; Exosome Component 1; CSL4; CGI-108; Csl4p; Ski4p; SKI4; P13; Exosome Complex Component CSL4; HCsl4p; Homolog Of Yeast Exosomal Core Protein CSL4; CSL4 Exosomal Core Protein Homolog (Yeast); 3'-5' Exoribonuclease CSL4 Homolog; Exosomal Core Protein CSL4; PCH1F |
| Immunogen | Recombinant protein of human EXOSC1 |
| Gene ID | 51013 |
|---|---|
| Other Names | Exosome complex component CSL4, Exosome component 1, EXOSC1, CSL4 |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | EXOSC1 |
|---|---|
| Synonyms | CSL4 |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8. |
| Cellular Location | Nucleus, nucleolus. Nucleus. Cytoplasm |
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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